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KU-60019,≥97% (HPLC)

别名:(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide ;KU60019

CAS号 925701-49-1 经验分子式(希尔表示法) C30H33N3O5S 分子量 547.67 MDL number MFCD19690944 PubChem Substance ID 329825862 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1416
CAS号: 925701-49-1
MDL号: MFCD19690944
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¥1,164.07

产品描述

一种ATM激酶抑制剂,IC50 为 6.3 nM。

Application

KU-60019 has been used to block ataxia telangiectasia mutated (ATM), to study its association of with the regulation of H2AX (H2A histone family, member X) and apoptosis inducing factor (AIF)-mediated cell death.[1]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

KU-60019 is a potent inhitor of ATM (ataxia telangiectasia mutated) kinase, a member of phosphatidylinositol-3-kinase-related kinase family that is critical in regulating cell cycle checkpoints and DNA repair. KU-60019 has an IC50 value of 6.3 nM. KU-60019 radiosensitizes U1242 human glioma cells, and also blocks U1242 cell migration and invasion through matrigel.

Other Notes

KU-60019 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the KU-60019 probe summary on the Chemical Probes Portal website.

性质

Quality Level  100
assay  ≥97% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 20 mg/mL, clear
storage temp.  −20°C
SMILES string  O=C(CN1C[C@H](C)O[C@H](C)C1)NC(C=C2)=CC3=C2SC4=C(C5=CC(C=C(N6CCOCC6)O5)=O)C=CC=C4C3
InChI  1S/C30H33N3O5S/c1-19-16-32(17-20(2)37-19)18-28(35)31-23-6-7-27-22(13-23)12-21-4-3-5-25(30(21)39-27)26-14-24(34)15-29(38-26)33-8-10-36-11-9-33/h3-7,13-15,19-20H,8-12,16-18H2,1-2H3,(H,31,35)/t19-,20+
InChI key  SCELLOWTHJGVIC-BGYRXZFFSA-N


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16