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K858,≥98% (HPLC)

别名:K 858;N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide;N-(4-乙酰基-4,5-二氢-5-甲基-5-苯基-1,3,4-噻二唑-2-基)乙酰胺

CAS号 72926-24-0 经验分子式(希尔表示法) C13H15N3O2S 分子量 277.34 MDL number MFCD00181155 PubChem Substance ID 329817139 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): K3644
CAS号: 72926-24-0
MDL号: MFCD00181155
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¥1,190.23

产品描述

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to off-white
solubility  DMSO: ≥20 mg/mL
storage temp.  2-8°C
SMILES string  CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
InChI  1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
InChI key  JEFVYQYZCAVNTP-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
危害码 (欧洲) Xn
风险声明 (欧洲) 22
RIDADR NONH for all modes of transport
WGK德国 WGK 1
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16