KRN633，≥98% (HPLC)

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别名：KRN-633；N-[2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N′-propyl-urea；N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲

CAS号 286370-15-8 经验分子式（希尔表示法） C20H21ClN4O4 分子量 416.86 NACRES NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: SML0957

CAS号: 286370-15-8

MDL号: MFCD14155620

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目录价.SKU-Variant

5mg
25mg [+¥2,210.13]
100mg [+¥6,876.21]

¥1,456.76

数量:

产品描述

一种VEGFR1/2/3的ATP竞争性抑制剂，IC50分别为170 nm、160 nm和125 nm。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

KRN633 is a cell-permeable; reversible and ATP-competitive inhibitor of vascular endothelial growth factor receptor tyrosine kinase (VEGFR) with IC₅₀ values of 170, 160, and 125 nM for VEGFR-1, -2, -3, respectively. Krn633 inhibits PDGFR-α and c-Kit only at higher concentrations (IC₅₀= 0.97 and 4.33 μM, respectively) and is inactive towards a panel of 17 other kinases (IC₅₀ >/= 10 μM).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

性质

Quality Level	100
assay	≥98% (HPLC)
form	powder
color	white to beige
solubility	DMSO: 3 mg/mL, clear (warmed)
storage temp.	−20°C

安全信息

符号

GHS07

信号词 Warning

危害声明 H302

危害码 (欧洲) Xn

风险声明 (欧洲) 22

RIDADR NONH for all modes of transport

WGK德国 WGK 3

商品规格

属性名称	属性值
储存温度 Storage temp.	-20°C低温冷冻
全球实时库存 Availability √	美国St. Louis ≥ 99 \| 欧洲Eur. ≥ 10 \| 東京Tokyo ≥ 22 \| 香港与北京 ≥ 32

KRN633，≥98% (HPLC)

产品描述

包装

Biochem/physiol Actions

Features and Benefits

性质

安全信息

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