IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.
5, 25 mg in glass bottle
IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.
IOX2是脯氨酰羟化酶（PHD）的选择性强效抑制剂。 已经通过抑制PHD来稳定HIF-1R，作为治疗缺血性疾病（包括贫血，心肌梗塞和中风）的一种潜在方法。 IOX2是缺氧诱导因子（HIF）脯氨酰羟化酶（PHD）的选择性抑制剂，在斑马鱼中表现出HIF1a的上调。 有关完整表征的详细信息，请访问结构基因组学联盟（SGC）网站上的IOX2探针摘要。
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Features and Benefits
IOX2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
|Quality Level ||100|
|assay ||≥98% (HPLC)|
|color ||white to beige|
|solubility ||DMSO: 5 mg/mL, clear (warmed)|
|storage temp. ||2-8°C|
|SMILES string ||OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O|
|InChI key ||CAOSCCRYLYQBES-UHFFFAOYSA-N|
RIDADR UN 2811 6.1 / PGIII