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IOX2,≥98% (HPLC)

别名:JICL38;N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine, N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine

CAS号 931398-72-0 经验分子式(希尔表示法) C19H16N2O5 分子量 352.34 MDL number MFCD22580424 PubChem Substance ID 329825575 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0652
CAS号: 931398-72-0
MDL号: MFCD22580424
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¥1,259.84

产品描述

一种选择性的和有效的脯氨酰羟化酶(PHD2)抑制剂。

Application

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.[1]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.

IOX2是脯氨酰羟化酶(PHD)的选择性强效抑制剂。 已经通过抑制PHD来稳定HIF-1R,作为治疗缺血性疾病(包括贫血,心肌梗塞和中风)的一种潜在方法。 IOX2是缺氧诱导因子(HIF)脯氨酰羟化酶(PHD)的选择性抑制剂,在斑马鱼中表现出HIF1a的上调。 有关完整表征的详细信息,请访问结构基因组学联盟(SGC)网站上的IOX2探针摘要。

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

Features and Benefits

IOX2 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 5 mg/mL, clear (warmed)
storage temp.  2-8°C
SMILES string  OC(C1=C(N2CC3=CC=CC=C3)C=CC=C1)=C(C(NCC(O)=O)=O)C2=O
InChI  1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
InChI key  CAOSCCRYLYQBES-UHFFFAOYSA-N


安全信息

符号 
GHS06  GHS06
信号词 Danger
危害声明 H301
警示性声明 P301 + P310
危害码 (欧洲) T
风险声明 (欧洲) 25
安全声明 (欧洲) 45
RIDADR UN 2811 6.1 / PGIII
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16