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GSK591,≥97% (HPLC)

别名:GSK3203591, GSK 591, 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide., EPZ015866

Empirical Formula (Hill Notation): C22H28N4O2 CAS号: 1616391-87-7 分子量: 380.48 MDL编号: MFCD30187524 PubChem化学物质编号: 329826054 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1751
CAS号: 1616391-87-7
MDL号: MFCD30187524
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$354.21

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

GSK591 is also known as 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide, EPZ015866 and GSK3203591. It prevents the systemic arginine methylation of SmD3 (small nuclear ribonucleoprotein).
GSK591 is a SGC probe for PRMT5. GSK591 is a potent and selective inhibitor of H4 histone methylation by PRMT5/MEP50 complex. For full characterization details, please visit the GSK591 probe summary on the Structural Genomics Consortium (SGC) website.

SGC2096 is the negative control for the active probe, GSK-591. To request a sample of the negative control from the SGC, click here.
To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
 
GSK591 也称为 2-(环丁基氨基)-N-[(2S)-3-(3,4-二氢-2(1H)-异喹啉基)-2-羟丙基]-4-吡啶甲酰胺,EPZ015866 和 GSK3203591。 它可以防止 SmD3(小核核糖核蛋白)的全身精氨酸甲基化。
GSK591 是 PRMT5 的 SGC 探针。 GSK591 是一种有效的选择性抑制剂,通过 PRMT5/MEP50 复合物抑制 H4 组蛋白甲基化。
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
GSK591 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

其他说明

GSK591 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK591 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 20 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC=NC(NC4CCC4)=C3

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16