sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

CP-809101 fumarate,≥98% (HPLC)

别名:CP809101富马酸盐;2-(3-Chlorobenzyloxy)-6-(piperazin-1-yl)pyrazine fumarate;2-(3-氯苄氧基)-6-(哌嗪-1-基)吡嗪富马酸酯

Empirical Formula (Hill Notation): C15H17ClNO4 · C4H4O4 CAS号: 479683-64-2 (free base) 分子量: 426.82 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0378
CAS号: 479683-64-2
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$410.11

说明

生化/生理作用

CP-809,101 is a potent and high-affinity 5-hydroxytryptamine receptor 2C (5-HT2C) full agonist with only weaker partial agonist activity toward 5-HT2A & 5-HT2B (cellular Ca2+ mobilization EC50 in nM/efficiency = 0.11/93% and 0.06/97% with human and rat 5-HT2C, respectively; 153/67%/human 5HT2A, 65.3/57%/human 5HT2B, 119/79%/rat 5HT2A) and much reduced or little affinity toward other receptors, ion channels and uptake sites tested. CP-809,101 exhibits antipsychotic efficacy in reducing conditioned avoidance response/CAR (ED50 = 4.8 mg/kg s.c.) and locomotor activity (ED50 in mg/kg via s.c. = 2/rats, 1/mice; no effect up to 10 mg/kg in 5-HT2C-knockout mice), while oral administration is reported to suppress spontaneous and nocturnal food intake as well as fasting-induced refeeding in rats (∼8% and ∼24% reduction of cumulative food intake and body weight in 4 days, respectively; 30 mg/kg/day p.o.).
 
CP-809,101 是一种有效且高亲和力的 5-羟色胺受体 2C (5-HT2C) 完全激动剂,对 5-HT2A 和 5-HT2B 的部分激动剂活性较弱(细胞 Ca2+ 动员 EC50,nM/效率 = 0.11/93% 和 0.06/97% 与人和大鼠 5-HT2C,分别为 153/67%/人 5HT2A,65.3/57%/人 5HT2B,119/79%/大鼠 5HT2A) 和对其他受体的亲和力大大降低或很少,离子 通道和吸收位点进行了测试。 CP-809,101 在降低条件性回避反应/CAR(ED50 = 4.8 mg/kg sc)和运动活动(ED50 以 mg/kg 为单位,通过 sc = 2/大鼠,1/小鼠;高达 10 mg/kg 时无效果)方面表现出抗精神病功效 在 5-HT2C 基因敲除小鼠中),而据报道口服给药可抑制自发和夜间食物摄入以及禁食诱导的大鼠再进食(4 天内累积食物摄入量和体重减少约 8% 和约 24%, 分别为;30 mg/kg/天 po)。
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

white to beige

创始人

Pfizer

储存温度

−20°C

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16