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CP-101606,≥98% (HPLC)

别名:CP101606;Traxoprodil;(1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol;(1s,2s)-1-[4-羟苯基]-2-(4-羟基-4-苯哌啶基)-1-丙醇

Empirical Formula (Hill Notation): C20H25NO3 CAS号: 134234-12-1 分子量: 327.42 MDL编号: MFCD00926469 PubChem化学物质编号: 329825120 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0053
CAS号: 134234-12-1
MDL号: MFCD00926469
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$252.15

说明

一般描述

CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.
 

应用

CP-101,606 has been used as a N-methyl-D-aspartate (NMDA) receptor antagonist to study its role in recovery of spinal cord injuries.
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.
CP-101,606 (Traxoprodil) plays a role in inhibiting glutamate-induced death in rats. It may exhibit therapeutic effects against human ischemia and neurodegenerative disorders. Traxoprodil is metabolized by cytochrome P450 (CYP) 2D6.
Traxoprodil (CP-101,606) 是一种有效的非竞争性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂,对 NR2B 亚基具有选择性。 它已被证明在脑损伤和中风的动物模型中具有神经保护作用。
CP-101,606 (Traxoprodil) 在抑制谷氨酸诱导的大鼠死亡中发挥作用。 它可能对人类缺血和神经退行性疾病表现出治疗作用。 Traxoprodil 由细胞色素 P450 (CYP) 2D6 代谢。
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 

属性

测定

≥98% (HPLC)

形式

powder

旋光性

α/D +50 to +60° (c=1, MeOH)

颜色

white to tan

溶解性

DMSO: ≥35 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

CC@@H(C@@H(O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3

InChI

1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1

InChI key

QEMSVZNTSXPFJA-HNAYVOBHSA-N

Gene Information

human ... GRIN1(2902), GRIN2B(2904)

 

安全信息

危害代码

T,N

风险声明

25-36-50

安全声明

26-45-61

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16