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CNQX二钠盐水合物,CNQX disodium salt hydrate;≥98% (HPLC), solid

别名:6-氰-7-硝基喹喔啉-2,3-二酮二钠盐水合物;6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate, FG-9065

CAS号 115066-14-3 (free base) 经验分子式(希尔表示法) C9H2N4Na2O4 · xH2O 分子量 276.12 (anhydrous basis) MDL number MFCD09953908 PubChem Substance ID 24277972 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C239
CAS号: 115066-14-3
MDL号: MFCD00069232
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$314.17

产品描述

Application

CNQX disodium salt hydrate has been used as:
• as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
• as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
• as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

包装

5, 25, 100 mg in glass bottle

Biochem/physiol Actions

CNQX(6-cyano-7-nitroquinoxaline-2,3-dioneis) is a potent, competitive AMPA/kainate receptor antagonist.[2] It is a quinoxaline derivative and also an antagonist for non-N-methyl-d-aspartate (non-NMDA) glutamate receptor. CNQX mediates depolarization thalamic reticular nucleus via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs).[1] It displays micromolar affinity towards AMPA/kainate receptor.[3]

强效、竞争性 AMPA/红藻氨酸受体拮抗剂。

Features and Benefits

这种化合物也是Sigma美国药理活性化合物库(LOPAC®1280)的一部分,该库是一个高质量的、可直接筛选的化合物的生物学注释集合。点击此处了解更多信息。

这种化合物是神经科学研究的特色产品。 点击此处 ,发现更多特色神经科学产品。在 sigma.com/discover-bsm 了解更多关于其他研究领域的生物活性小分子。

法律信息

LOPAC 为以下机构的注册商标: Sigma-Aldrich Co. LLC

性质

Quality Level  100
assay  ≥98% (HPLC)
form  solid
storage condition  protect from light
color  orange to red
solubility  DMSO: >20 mg/mL
 H2O: >5 mg/mL
SMILES string  O.[Na+].[Na+].[O-]c1nc2cc(C#N)c(cc2nc1[O-])[N+]([O-])=O
InChI  1S/C9H4N4O4.2Na.H2O/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;;/h1-2H,(H,11,14)(H,12,15);;;1H2/q;2*+1;/p-2
InChI key  LCDWHGXMFAZHEO-UHFFFAOYSA-L
Gene Information  human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32