草酰乙酸，Oxaloacetic acid；powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

图片 草酰乙酸，Oxaloacetic acid；powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)
别名：草乙酸；2-氧代丁二酸；丁酮二酸；氧代丁二酸；草醋酸；2-Oxosuccinic acid, Ketosuccinic acid, Oxalacetic acid, Oxobutanedioic acid

线性分子式: HOOCCH2COCOOH CAS号: 328-42-7 分子量: 132.07 Beilstein: 1705475 EC 号: 206-329-8 MDL编号: MFCD00002592 PubChem化学物质编号: 24898047 NACRES: NA.75
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: O7753
CAS号: 328-42-7
MDL号: MFCD00002592
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

草酰乙酸是一种二羧酸，存在于体内的每个细胞中。它是三羧酸（TCA）循环和糖异生的代谢中间体。
草酰乙酸已被用于评估其对肌萎缩侧索硬化症（ALS）模型超氧化物歧化酶1（SOD1）G93A小鼠神经肌肉功能和寿命的影响。它还被用作Dulbecco改良鹰培养基（DMEM）的补充剂，用于培养鸡成纤维细胞（DF-1）细胞和化学永生化的腿角雄性肝癌（LMH）细胞，用于功能验证实验。
草酰乙酸在中枢代谢中起着至关重要的作用。它抑制琥珀酸脱氢酶，是线粒体代谢的关键调节因子。

一般描述

Oxaloacetic acid is a dicarboxylic acid that is present in every cell in the body. It is a metabolic intermediate of the tricarboxylic acid (TCA) cycle and gluconeogenesis.
 

应用

Oxaloacetic acid has been used to evaluate its effect on neuromuscular function and lifespan in amyotrophic lateral sclerosis (ALS) model superoxide dismutase 1 (SOD1) G93A mice. It has also been used as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to culture chicken fibroblast (DF-1) cells and chemically immortalized leghorn male hepatoma (LMH) cells for functional validation experiments.
 

生化/生理作用

Oxaloacetic acid plays a vital role in central metabolism. It inhibits succinate dehydrogenase and is a key regulator of mitochondrial metabolism.
 
 

属性

生物来源

synthetic (organic)

质量水平

200

产品线

BioReagent

测定

≥97% (HPLC)

形式

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

溶解性

H2O: 100 mg/mL

储存温度

−20°C

SMILES string

OC(=O)CC(=O)C(O)=O

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H319

危险分类

Eye Irrit. 2

储存分类代码

8B - Non-combustible, corrosive hazardous materials

WGK

WGK 1

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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