盐酸阿米洛利水合物，Amiloride hydrochloride hydrate [HMA]；≥98% (HPLC), powder

图片 盐酸阿米洛利水合物，Amiloride hydrochloride hydrate [HMA]；≥98% (HPLC), powder
别名：盐酸氨氯吡咪；阿米洛利盐酸盐；盐酸阿米咯利；盐酸阿米洛利二水合物；Amiloride hydrochloride hydrate；Hexamethyleneamiloride；N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate；17440-83-4

Empirical Formula (Hill Notation): C6H8ClN7O · HCl · xH2O CAS号: 2016-88-8 分子量: 266.09 (anhydrous basis) MDL编号: MFCD03703482 PubChem化学物质编号: 24277817 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: A7410
CAS号: 2016-88-8
MDL号: MFCD03703482
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

阿米洛利是选择性T型钙通道阻滞剂，上皮钠通道阻滞剂和尿激酶纤溶酶原激活物（uPA）的选择性抑制剂。阿米洛利已被用于研究开发便秘的替代疗法。
选择性T型钙通道阻滞剂和上皮钠通道阻滞剂。尿激酶纤溶酶原激活物（uPA）的选择性抑制剂。

应用

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.
 

生化/生理作用

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).
 

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

注意

Protect from light.
 
 

属性

质量水平

200

测定

≥98% (HPLC)

形式

powder

颜色

yellow

mp

285-288 °C (dec.)

溶解性

H2O: 50 mg/mL, clear, yellow-green

创始人

Perrigo

储存温度

room temp

SMILES string

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

InChI key

WDZJJRLYFQNCQL-UHFFFAOYSA-N

Gene Information

human ... ABP1(26) , ACCN1(40) , ACCN2(41) , PLAU(5328) , SCNN1A(6337) , SCNN1B(6338) , SCNN1D(6339) , SCNN1G(6340) , SLC9A1(6548) , TNF(7124)
mouse ... Abp1(76507) , Accn1(11418) , Accn2(11419) , Plau(18792) , Scnn1a(20276) , Scnn1b(20277) , Scnn1d(140501) , Scnn1g(20278) , Slc9a1(20544)
rat ... Abp1(65029) , Accn1(25364) , Accn2(79123) , Plau(25619) , Scnn1a(25122) , Scnn1b(24767) , Scnn1g(24768) , Slc9a1(24782)

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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