烟曲霉素，Fumagillin from Aspergillus fumigatus；≥90%, powder

图片 烟曲霉素，Fumagillin from Aspergillus fumigatus；≥90%, powder
别名: Fugillin Empirical Formula (Hill Notation): C26H34O7 CAS号: 23110-15-8 分子量: 458.54 EC 号: 245-433-8 MDL编号: MFCD03990453 PubChem化学物质编号: 24894920
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: F6771
CAS号: 23110-15-8
MDL号: MFCD03990453
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说明

一般描述

Fumagillin is a metabolic product of fungi. It is originally isolated from Aspergillus fumigatus.[1]
 

应用

Fumagillin from Aspergillus fumigatus has been used:
  • in chick chorioallantoic membrane (CAM) assay to study the changes in protein expression in response to anti-angiogenic agent[2]
  • to study its effects on the mortality of caged Nosema ceranae-infected honey bees- write in this way [3]
  • as a positive control in in vitro and ex vivo studies[4]

生化/生理作用

Fumagillin is known to be effective against microsporidian fungal infections.[1]
Methionine aminopeptidase-2 (MetAP-2) inhibitor; inhibits endothelial cell proliferation and angiogenesis.
 
 

属性

生物来源

Aspergillus sp. (Aspergillus fumigatus)

质量水平

200

测定

≥90%

形式

powder

颜色

white

mp

197-198  °C

溶解性

ethanol: 1 mg/mL

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

−20°C

SMILES string

COC1C(CCC2(CO2)C1C3(C)OC3C\C=C(\C)C)OC(=O)\C=C\C=C\C=C\C=C\C(O)=O

InChI

1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+

InChI key

NGGMYCMLYOUNGM-HCNIIHBUSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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