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质粒DNA纯选疏水层析树脂,Capto PlasmidSelect

用于纯化超螺旋 DNA 的层析树脂,用于基因治疗和 DNA 疫苗应用的高质量。17549901;17549902;17549904;17549903
货号(SKU): 17549903
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥43,088

Chromatography resin designed for purification of supercoiled DNA to high quality for gene therapy and DNA vaccine applications.

Capto PlasmidSelect 允许将质粒 DNA 的超螺旋共价闭合环状形式与开放环状形式分开。

从研究规模到 cGMP 生产的超螺旋 DNA 的高流量纯化。
由于流速和床高的操作窗口很大,因此工艺设计灵活。
更高的吞吐量以提高生产力和流程经济性。
基础基质的亲水特性可防止非特异性结合。
BioProcess 树脂支持工业应用。
Capto PlasmidSelect 基于刚性基础基质,为质粒生产提供出色的压力流动特性。

Capto PlasmidSelect allows supercoiled covalently closed circular forms of plasmid DNA to be separated from open circular forms.

  • High-flow purification of supercoiled DNA from research scale to cGMP production.
  • Flexible process design due to a large operational window of flow velocities and bed heights.
  • Higher throughput for improved productivity and process economy.
  • Hydrophilic properties of base matrix prevent non-specific binding.
  • BioProcess resin supported for industrial applications.

Capto PlasmidSelect is based on a rigid base matrix, delivering excellent pressure-flow properties to plasmid production.

Learn more about prepacked HiScreen Capto PlasmidSelect and HiTrap Capto PlasmidSelect columns.

 

ParameterCapto PlasmidSelect
BioProcess resinYes 
Ligand2-mercaptopyridine 
Particle size, d50V136–44 μm 
MatrixHighly cross-linked agarose, spherical 
pH stability, operational23 to 13 
pH stability, CIP32 to 14 
Flow velocity4220 cm/h 
Chemical stabilityStable in up to 1 M NaOH, 40% Isopropanol, up to 1 M acetic acid, and up to 70% ethanol. 
Binding capacity/mL chromatography resin5≥ 3.0 mg/mL 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH range where resin can be subjected to cleaning-in-place (CIP) without significant change in function.
  • 4Packed in a 1 m diameter column at 20 cm bed height, using buffers with the same viscosity as water at 20°C at < 3 bar (0.3 MPa).
  • 5No breakthrough observed at a flow velocity of 200 cm/h in a HiScreen column (3 min residence time) equilibrated with 100 mM Tris, 2 M AS, 10 mM EDTA, pH 7.5.
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16