<br /> Empirical Formula (Hill Notation): C14H19NO4 CAS号: 22862-76-6 分子量: 265.30 Beilstein: 20705 EC 号: 245-269-7 MDL编号: MFCD00077650 PubChem化学物质编号: 24891496 NACRES: NA.77">
从灰链霉菌中分离出的抑制蛋白质合成的抗生素。通过抑制真核生物核糖体中的肽基转移酶活性而起作用。据报道,可诱导多种细胞凋亡,包括早幼粒细胞白血病细胞、Jurkat细胞、心室肌细胞和结肠腺癌细胞。启动细胞内信号并立即进行早期基因诱导。选择性信号激动剂。强效Jun-NH2末端激酶(JNK)激动剂。激活丝裂原激活蛋白(MAP)激酶(JNK/SAPK和p38/RK)。抗原虫剂。
300
≥98% (HPLC)
solid
white to faint yellow
H2O: 2 mg/mL (Aqueous solutions are stable over a wide range of pH at room temperature.)DMSO: 20 mg/mLmethanol: 20 mg/mL
neoplastics
protein synthesis | interferes
2-8°C
COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
YKJYKKNCCRKFSL-RDBSUJKOSA-N
Danger
Acute Tox. 3 Oral
6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK 3
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges