General description
Chemical structure: ß-lactam
Application
Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases,[1] to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections,[3] and to study pneumococcal pneumonia and the pharmokinetics of various treatments.[2] It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis.
Biochem/physiol Actions
Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.
Other Notes
Broad spectrum third generation cephalosporin antibiotic.
Keep container tightly closed in a dry and well-ventilated place.