头孢噻肟钠盐 [噻孢霉素]，Cefotaxime sodium salt；potency: 916-964 μg per mg

General description

Chemical structure: ß-lactam

Application

Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases,^[1] to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections,^[3] and to study pneumococcal pneumonia and the pharmokinetics of various treatments.^[2] It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Keep container tightly closed in a dry and well-ventilated place.

性质

安全信息

符号

  GHS08

信号词 Danger

危害声明 H317 - H334

警示性声明 P261 - P280 - P342 + P311

个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves

危害码 (欧洲) Xn

风险声明 (欧洲) 42/43

安全声明 (欧洲) 22-36/37

RIDADR NONH for all modes of transport

WGK德国 WGK 2

RTECS XI0250000