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头孢噻肟钠盐 [噻孢霉素],Cefotaxime sodium salt;potency: 916-964 μg per mg

别名:头孢霉素;头孢赛肟钠盐;头孢噻吩钠盐;Cefotaxim sodium salt;7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7²-(Z)-(O-methyloxime) Acetate, Na, Cefotaxim sodium salt

CAS号 64485-93-4 经验分子式(希尔表示法) C16H16N5NaO7S2 分子量 477.45 Beilstein/REAXYS Number 5711411 EINECS 编号 264-915-9 MDL number MFCD00079073 PubChem Substance ID 24278336 NACRES NA.85
货号(SKU): C7912
CAS号: 64485-93-4
MDL号: MFCD00079073
增值税发票 √ 免费货运 [顺丰 联邦] √
¥2,330.00

产品描述

头孢噻肟钠盐, 属第三代头孢类抗生素

General description

Chemical structure: ß-lactam

Application

Cefotaxim has been used to find new residues involved in cefotaxime hydrolysis in CTX-M β-lactamases,[1] to study antibiotic-susceptible and -resistant Streptococcus pneumoniae infections,[3] and to study pneumococcal pneumonia and the pharmokinetics of various treatments.[2] It may be used to study the effects of binding and inhibition of penicillin binding protein 2 (PBP2) on bacterial mucopeptide synthesis.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Keep container tightly closed in a dry and well-ventilated place.

性质

Quality Level200
formpowder
potency916-964 μg per mg
solubilityH2O: 50 mg/mL
Mode of actioncell wall synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
storage temp.2-8°C
SMILES string[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O
InChI1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1
InChI keyAZZMGZXNTDTSME-JUZDKLSSSA-M


安全信息

符号
GHS08  GHS08
信号词 Danger
危害声明 H317 - H334
警示性声明 P261 - P280 - P342 + P311
危害码 (欧洲) Xn
风险声明 (欧洲) 42/43
安全声明 (欧洲) 22-36/37
RIDADR NONH for all modes of transport
WGK德国 WGK 2
RTECS XI0250000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62