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粉防己碱,Tetrandrine [TET];≥98% (HPLC)

别名:倒地拱素;(S,S)-Tetrandrine, (1β)-6,6′,7,12-Tetramethoxy-2,2′-dimethylberbaman, NSC 77037, Tetrandrin, (+)-Tetrandrine, (4aS,16aS)-3,4,4a,5,16a,17,18,19-Octahydro-12,21,22,26-tetramethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2′,3′:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline

Empirical Formula (Hill Notation): C38H42N2O6 CAS号: 518-34-3 分子量: 622.75 MDL编号: MFCD08689909
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML3048
CAS号: 518-34-3
MDL号: MFCD08689909
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说明

粉防己碱是一种双苄基异喹啉生物碱,从千金藤 S Moore 中提取,具有多种药理活性,包括抗癌、抗炎、负离子和变时作用,对心肌、免疫和抗过敏作用。 它已被用于治疗肺结核、高血糖症、疟疾、癌症和发烧。 粉防己碱是有效的钙通道阻滞剂。 粉防己碱靶向控制细胞周期、细胞凋亡的多种信号通路。 粉防己碱是一种外排泵抑制剂,可逆转某些鸟分枝杆菌复合体临床分离株的克拉霉素耐药表型。

生化/生理作用

Tetrandrine is bisbenzylisoquinoline alkaloid extracted from isolated from Stephania tetrandra S Moore that exhibits numerous pharmacological activities including anti-cancer, anti-inflammatory, negative ionotropic and chronotropic effects on myocardium, immunologic and antiallergenic effects. It has been used for treatment of tuberculosis, hyperglycemia, malaria, cancer and fever. Tetrandrine is potent calcium channel blocker. Tetrandrine targets multiple signaling pathways controlling cell cycle, apoptosis. Tetrandrine is an inhibitor of efflux pumps that reversed the clarithromycin resistance phenotype of some Mycobacterium avium complex clinical isolates.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES string

COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34

InChI

1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1

InChI key

WVTKBKWTSCPRNU-KYJUHHDHSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 2 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
商品标签 [tags]