sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

Tenidap,≥97% (HPLC)

别名:(3Z)-5-Chloro-2,3-dihydro-3-(hydroxy-2-thienylmethylene)-2-oxo-1H-indole-1-carboxamide, CP 66248

Empirical Formula (Hill Notation): C14H9ClN2O3S CAS号: 120210-48-2 分子量: 320.75 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0196
CAS号: 120210-48-2
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$367.75

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

Tenidap is an anti-inflammatory and anti-rheumatic with a variety of activities. Tenidap preferentially inhibits COX-1 with an IC50 value of 30 nM, and also has some lesser inhibitory activity towards COX-2 and 5-lipoxygenase (IC50 values are 1.2 and > 30 μM for COX-2 and 5-lipoxygenase respectively). Tenidap is also a cytokine modulator, an opener of inward rectifying hKIR2.3 channels (EC50 = 402 nM) and has been shown to modulate cytoplasmic pH and inhibit anion transport in vitro.
 
Tenidap 是一种具有多种活性的抗炎和抗风湿药。 Tenidap 优先抑制 COX-1,IC50 值为 30 nM,并且对 COX-2 和 5-脂氧合酶的抑制活性较低(COX-2 和 5-脂氧合酶的 IC50 值分别为 1.2 和 > 30 μM)。 Tenidap 还是一种细胞因子调节剂,一种内向整流 hKIR2.3 通道 (EC50 = 402 nM) 的开启剂,并已被证明可调节细胞质 pH 值并抑制体外阴离子转运。
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
 

其他说明

This compound was developed by Pfizer for Lipid Signaling research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

mfr. no.

Pfizer®

颜色

faintly yellow to dark yellow

溶解性

DMSO: 1 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

2-8°C

InChI

1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)

InChI key

IZSFDUMVCVVWKW-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危害代码

Xn

风险声明

22

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16