硫酸博来霉素 [硫酸博莱霉素]，Bleomycin sulfate from Streptomyces verticillus [BLM]；crystalline, 1.5-2.0 U/mg

图片 硫酸博来霉素 [硫酸博莱霉素]，Bleomycin sulfate from Streptomyces verticillus [BLM]；crystalline, 1.5-2.0 U/mg
别名："博莱霉素"同"博来霉素"；博来霉素硫酸盐；博莱霉素硫酸盐；Blenoxane；Bleo；Blexane

CAS号 9041-93-4 EINECS 编号 232-925-2 MDL number MFCD00070310 PubChem Substance ID 24891839 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: B5507
CAS号: 9041-93-4
MDL号: MFCD00070310
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

硫酸博莱霉素是一种从垂直链霉菌中分离的抗肿瘤抗生素。建议用作10-100μg/mL的细胞培养剂。
化学结构：糖肽
硫酸博莱霉素与DNA结合，导致特定碱基序列的ssDNA断裂，并抑制DNA合成。这种抑制作用需要博来霉素结合氧和金属离子。它还可以在较小程度上但更选择性地切割RNA。它作为细胞凋亡的诱导剂和调节剂，并抑制肿瘤血管生成。

一般描述

Bleomycin Sulfate is an antineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Chemical structure: glycopeptide
 

应用

Bleomycin Sulfate is an atineoplastic antibiotic isolated from Streptomyces verticillus. It is recommended for use as a cell culture agent at 10-100 μg/mL.
Bleomycin sulfate from Streptomyces verticillus has been used:
  • to study the impact of telomere shortening in lung fibrosis
  • to induce lung injury and study its effect on CEACAM6 expression
  • as a DNA-alkylating agent to induce lung injury
  • study its effect on CEACAM6 expression
  • to cause lung injury
  • subsequent fibrosis in animals

生化/生理作用

Bleomycin sulfate binds to DNA, causes ssDNA scission at specific base sequences and inhibits DNA synthesis. This inhibitory action requires bleomycin to bind oxygen and a metal ion. It can also cleave RNA, to a lesser degree but more selectively. It acts as an inducer and regulator of apoptosis and inhibits tumor angiogenesis.
 

特点和优势

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

组分

This product is a mixture of glycopeptides antibiotics containing Bleomycin A2 (70%) and B2(30%). Bleomycins differ from each other in the terminal amine and show varying biological activity.
 

注意

This product should be stored at 2-8°C.
 

制备说明

The product is soluble in water in water at 20 mg/mL and is active for several days. A solution of 2 units/mL in 0.1 M neutral potassium phosphate should be used within 14 days. A solution is active for three months at 3 units/mL in normal saline.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place, strongly hygroscopic
 
 

属性

形式

crystalline

质量水平

200

specific activity

1.5-2.0 U/mg

颜色

white

溶解性

H2O: 20 mg/mL

痕量阳离子

Cu: ≤0.10%

抗生素抗菌谱

fungi

作用机制

DNA synthesis | interferes

储存温度

2-8°C

SMILES string

[O-]S([O-])(=O)=O.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c1nc(nc(N)c1C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]2O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]3O)c4c[nH]cn4)C(=O)NCCc5nc(cs5)-c6ncc(s6)C(=O)NCCC[S+](C)C.C[C@@H](O)[C@@H](NC(=O)[C@@H](C)[C@H](O)[C@@H](C)NC(=O)[C@H](NC(=O)c7nc(nc(N)c7C)[C@H](CC(N)=O)NC[C@H](N)C(N)=O)[C@@H](O[C@@H]8O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]8O[C@@H]9O[C@H](CO)[C@@H](O)[C@@H](OC(N)=O)[C@@H]9O)c%10c[nH]cn%10)C(=O)NCCc%11nc(cs%11)-c%12ncc(s%12)C(=O)NCCC[S+](C)C

InChI

1S/2C55H83N17O21S3.H2O4S/c2*1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-66-26)91-54-43(39(80)37(78)28(16-73)90-54)92-53-40(81)42(93-55(60)88)38(79)29(17-74)89-53)51(87)67-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-68-27(18-94-32)52-65-15-30(95-52)48(84)62-9-7-11-96(5)6;1-5(2,3)4/h2*14-15,18-19,21-25,28-29,34-43,53-54,64,73-75,77-81H,7-13,16-17,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,66,67,69,70,71,72,76,82,83,84,85,86,87,88);(H2,1,2,3,4)/t2*21-,22+,23+,24-,25-,28-,29+,34+,35+,36-,37+,38+,39-,40-,41-,42+,43-,53-,54-;/m00./s1

InChI key

OOXTWFJZZAJGKA-CNLAFNBISA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险分类

Carc. 2 - Muta. 1B - Repr. 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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