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甲状腺球蛋白来源于牛甲状腺,Thyroglobulin from bovine thyroid;powder, ≥90% (agarose gel electrophoresis)

CAS号: 9010-34-8 EC 号: 232-721-3 MDL编号: MFCD00132429 NACRES: NA.61
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): T1001
CAS号: 9010-34-8
MDL号: MFCD00132429
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€213.76

说明

包装

100, 500 mg in poly bottle
1, 5 g in poly bottle
 

应用

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
 

生化/生理作用

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.
 
 

属性

质量水平

200

生物来源

bovine thyroid

测定

≥90% (agarose gel electrophoresis)

形式

powder

分子量

~670 kDa

组成

Iodine, ≥0.20%

氮含量分析

13.0-16.0% total

灰分

≤4%

溶解性

H2O: 20 mg/mL

储存温度

−20°C

Gene Information

cow ... TG(280706)

 

安全信息

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16