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甲基盐霉素,Narasin from Streptomyces auriofaciens;≥98% (HPLC)

来自金链霉菌的纳拉辛;一种抗球虫药和离子载体抗菌剂;Empirical Formula (Hill Notation): C43H72O11 CAS号: 55134-13-9 分子量: 765.03 MDL编号: MFCD00133653 PubChem化学物质编号: 24897476 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): N1271
CAS号: 55134-13-9
MDL号: MFCD00133653
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38 997,12 ₽

说明

Narasin 是一种促进肠球菌生长的离子载体抗菌剂,特别是屎肠球菌和粪肠球菌。 它抑制家禽和哺乳动物的球虫感染,并用于涉及钠钙离子交换的研究。

在猪中施用 Narasin 可提高氮的消化率,从而降低粪便中的氮并增加大肠中丙酸的相对浓度。 聚醚离子载体,例如 Narasin,具有亲水的内部和疏水的外部。 亲脂性离子载体附着在革兰氏阳性菌富含脂质的细胞膜上。 离子载体结合 Na+、K+ 和 H+ 并促进它们跨细菌细胞膜的转移,导致革兰氏阳性细胞内部的 H+ 浓度增加。 因此,H+ ATPase 泵被激活以输送多余的 H+。 细胞耗尽其能量资源并降低发酵功能和细胞分裂。

应用

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.
 

包装

5, 25, 50 mg in serum bottle
 

生化/生理作用

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na+, K+, and H+ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H+ concentration on the inside of the Gram-positive cell. Therefore, the H+ ATPase pump is activated to transport out excess H+. The cell is depleted of its energy resources and reduces fermentative functions and cell division .
 
 

属性

质量水平

200

测定

≥98% (HPLC)

溶解性

methanol: soluble 20 mg/mL

作用机制

cell membrane | interferes

抗生素抗菌谱

Gram-positive bacteria
fungi
viruses

储存温度

2-8°C

SMILES string

CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O

InChI

1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)

InChI key

VHKXXVVRRDYCIK-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

预防措施声明

Hazard Classifications

Acute Tox. 2 Oral

Storage Class Code

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10