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潮霉素B,Hygromycin B;≥60% (HPLC), 45-60 mg/mL in H2O, γ-irradiated

别名:潮霉素B抗生素;潮霉素B来源于吸水链霉菌;湿霉素乙;效高素;潮霉素 B干粉;homomycin

Empirical Formula (Hill Notation): C20H37N3O13 CAS号: 31282-04-9 分子量: 527.52 Beilstein: 6755837 MDL编号: MFCD06795479 PubChem化学物质编号: 24895698 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): H5527
CAS号: 31282-04-9
MDL号: MFCD06795479
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说明

潮霉素B是一种氨基糖苷类抗生素,从吸湿链霉菌中分离得到。它已被用于研究70S核糖体易位水平的蛋白质合成和mRNA模板误读,作为一种抗病毒药物,通过选择性穿透病毒感染可渗透的细胞并抑制翻译,以及作为潮霉素抗性基因转化细胞的选择剂。建议将其用作100-800μg/mL的选择剂,特别是原核生物为100μg/mL,低等真核生物为200μg/mL以及高等真核生物150-400μg/mL。

一般描述

Chemical structure: aminoglycoside
 

应用

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It has been used to study protein synthesis at the level of the 70S ribosome translocation and mRNA template misreading, as an antiviral agent by selectively penetrating cells rendered permeable by virus infection and inhibiting translation, and as a selection agent for hygromycin resistance gene transformed cells. It is recommended for use as a selection agent at 100-800 μg/mL, specifically at 100 μg/mL for prokaryotes, 200 μg/mL for lower eukaryotes and 150-400 μg/mL for higher eukaryotes.
 

生化/生理作用

抗菌剂和抗真菌剂。作用方式:在原核生物和真核生物中,通过诱导 mRNA 模板的误读而抑制蛋白质合成。它可选择性透入因病毒感染而变得可渗透的细胞。
 

注意

Hygromycin B products should be stored as supplied at 2-8°C, and the dry solid is stable for at least 5 years if stored at 2-8°C. It is stable at 37°C for 30 days.
 

制备说明

This product is a solution that is =60% (HPAE), 45-60 mg/mL in H2O, and γ-irradiated .
 
 

属性

生物来源

Streptomyces hygroscopicus

质量水平

200

无菌性

γ-irradiated

测定

≥60% (HPLC)

浓度

45-60 mg/mL in H2O

颜色

yellow-brown to orange

抗生素抗菌谱

viruses

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES string

CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@@H]3OC4(O[C@H]([C@H](N)CO)[C@H](O)[C@H](O)[C@H]4O)O[C@H]23)[C@@H]1O

InChI

1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6-,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20+/m1/s1

InChI key

GRRNUXAQVGOGFE-XKIAHZFYSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal

储存分类代码

6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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