无活菌素 [铵离子载体I]，Nonactin；from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

别名：铵离子载体I；Ammonium ionophore I； Empirical Formula (Hill Notation): C40H64O12 CAS号: 6833-84-7 分子量: 736.93 Beilstein: 76434 EC 号: 229-911-3 PubChem化学物质编号: 24897566

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: N2286

CAS号: 6833-84-7

MDL号: MFCD03267283

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目录规格.SKU-Variant

5mg
25mg
100mg

说明

一般描述

Chemical structure: macrolide

应用

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation [1].

生化/生理作用

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) [2][3].

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

属性

生物来源

Streptomyces griseus

质量水平

300

描述

Natural macrotetrolide, may contain homologues (like monactin and dinactin)

测定

≥98.0% (Total homologs, HPLC)

形式

powder

溶解性

chloroform: soluble 10 mg/mL

抗生素抗菌谱

Gram-positive bacteria

作用机制

DNA synthesis | interferes
cell membrane | interferes

储存温度

2-8°C

SMILES string

C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1

InChI

1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-

InChI key

RMIXHJPMNBXMBU-QIIXEHPYSA-N

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 10 \| 欧洲Eur. ≥ 8 \| 東京Tokyo ≥ 6 \| 香港与北京 ≥ 60

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