胶原蛋白II型来源于牛鼻中隔,Collagen from bovine nasal septum;Bornstein and Traub Type II, powder

II型胶原蛋白;牛胶原蛋白II;CAS号 9007-34-5 EINECS 编号 232-697-4 MDL number MFCD00130825 NACRES NA.61
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C7806
CAS号: 9007-34-5
MDL号: MFCD00130825
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General description

Collagen is a fibrous protein, found in connective tissues, hard tissues, bone, dentin, cementum and also the mineralizing cartilage of the epiphyseal growth plate.[2]

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.


Collagen from bovine nasal septum has been used to coat the plates to estimate the levels of serum anti-cII IgG by enzyme-linked immunosorbent assay (ELISA).[4] It has also been used as a component in the emulsified agent to induce arthritis in rats.[5]

Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type 2. Collagen-type 2 has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.[1]


10 mg in poly bottle

5 mg in glass bottle

Biochem/physiol Actions

Collagen is the structural constituent of the dermis, which provides strength and support to the human skin. Variations in collagen participates in the aging process.[3]

Preparation Note

An acid soluble collagen soluble in dilute acetic acid at pH 3.0 (5 mg/ml), yielding an opalescent, colorless solution.

Collagen Type II is a triple helix composed of three α1(II) strands.

Prepared by a modification of the pepsin extraction procedure of Niyibizi, et al., J. Biol. Chem., 259, 14170 (1984).


Quality Level200
biological sourcebovine nasal septum
application(s)ELISA: suitable
solubilityaqueous acid: soluble
storage temp.2-8°C
Gene Informationbovine ... COL2A1(407142)


个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 155 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 78 | 香港与北京 ≥ 32