头孢噻肟钠盐 [噻孢霉素]，Cefotaxime sodium salt；Pharmaceutical Secondary Standard; Certified Reference Material

别名：头孢霉素；头孢赛肟钠盐；头孢噻吩钠盐；Cefotaxim sodium salt；7-[2-(2-Amino-4-thiazolyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 7²-(Z)-(O-methyloxime) Acetate, Na, Cefotaxim sodium salt

Empirical Formula (Hill Notation): C16H16N5NaO7S2 CAS号: 64485-93-4 分子量: 477.45 Beilstein: 5711411 MDL编号: MFCD00079073

制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco

货号（SKU）: PHR2099

CAS号: 64485-93-4

MDL号: MFCD00079073

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录规格.SKU-Variant

说明

头孢噻肟通过与青霉素结合蛋白（PBP）结合来抑制细菌细胞壁合成，所述青霉素结合蛋白抑制细菌细胞壁中肽聚糖合成的最终转肽步骤。结果，由于细胞壁自溶酶，细菌裂解。

一般描述

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

生化/生理作用

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

其他说明

Broad spectrum third generation cephalosporin antibiotic.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

附注

To see an example of a Certificate of Analysis for this material enter LRAB9060 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

属性

等级

certified reference material
pharmaceutical secondary standard

Agency

traceable to Ph. Eur. C0685000
traceable to USP 1097909

形式

powder

CofA

current certificate can be downloaded

包装

pkg of 1 g

储存温度

2-8°C

SMILES string

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H317 - H334

预防措施声明

P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 20 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 5 \| 香港与北京 ≥ 20

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