喷昔洛韦，Penciclovir；≥98.0%

图片 喷昔洛韦，Penciclovir；≥98.0%
别名：2-氨基-1,9-二氢-9-[4-羟基-3-(羟甲基)丁基]-6H-嘌呤-6-酮；2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one；BRL-39123

Empirical Formula (Hill Notation): C10H15N5O3 CAS号: 39809-25-1 分子量: 253.26 MDL编号: MFCD15142866 PubChem化学物质编号: 329819986
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: P0035
CAS号: 39809-25-1
MDL号: MFCD15142866
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说明

应用

Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV).
 

生化/生理作用

Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
 
 

属性

形式

powder

质量水平

100

溶解性

0.02 M potassium phosphate: soluble 2 mg/mL

抗生素抗菌谱

viruses

作用机制

DNA synthesis | interferes
enzyme | inhibits

SMILES string

NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1

InChI

1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

InChI key

JNTOCHDNEULJHD-UHFFFAOYSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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