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唑尼泊利特盐酸盐水合物,Zoniporide hydrochloride hydrate;≥98% (HPLC)

别名:N-(氨基亚氨基甲基)-5-环丙基-1-(5-喹啉基)-1H-吡唑-4-甲酰胺盐酸盐水合物;N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate

Empirical Formula (Hill Notation): C17H16N6O · xHCl · yH2O CAS号: 241800-98-6 (free base) 分子量: 320.35 (anhydrous free base basis) MDL编号: MFCD04113213 PubChem化学物质编号: 329825138 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0076
CAS号: 241800-98-6
MDL号: MFCD04113213
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$597.16

说明

应用

Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
Zoniporide hydrochloride hydrate 已被用于抑制大鼠模型中的钠氢交换剂异构体 1 (NHE-1)。 它还被用于细胞毒性试验和研究其对淋巴细胞脉络丛脑膜炎病毒增殖的影响。
Zoniporide hydrochloride hydrate 可用于 Na+/H+ 介导的细胞信号传导研究。
 

包装

10, 50 mg in glass bottle
 

生化/生理作用

Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to tan

溶解性

H2O: 2 mg/mL, clear (warmed)

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4

InChI

1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2

InChI key

UCIJUEGJEFJRMP-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16