猪卵泡刺激素 [促卵泡素, 促卵泡激素]，Follicle Stimulating Hormone from porcine pituitary [Follitropin, FSH, pFSH]；activity: ~2000 units/mg

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  • 猪卵泡刺激素 [促卵泡素, 促卵泡激素]，Follicle Stimulating Hormone from porcine pituitary [Follitropin, FSH, pFSH]；activity: ~2000 units/mg
图片 猪卵泡刺激素 [促卵泡素, 促卵泡激素]，Follicle Stimulating Hormone from porcine pituitary [Follitropin, FSH, pFSH]；activity: ~2000 units/mg
别名：猪FSH；卵泡刺激素来源于猪脑垂体；猪垂体卵泡刺激激素；背景卵泡刺激素；猪FSH；Follitropin；pFSH

CAS号: 9002-68-0 MDL编号: MFCD00131099 eCl@ss: 42020504 NACRES: NA.32
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: F2293
CAS号: 9002-68-0
MDL号: MFCD00131099
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说明

FSH（卵泡刺激素）蛋白由两个亚基组成-α和β，其中α亚基与LH、hCG和TSH相似，后者是糖蛋白激素。α亚基有一个糖基化位点，β亚基有两个。
来自猪垂体的卵泡刺激激素已用于卵丘-卵母细胞复合体的体外成熟、受精和共培养，以及从成年大鼠睾丸获得的原始生殖细胞和支持细胞的共培养。
FSH参与卵巢卵泡的生长和卵巢的类固醇生成。FSHR（卵泡刺激激素受体）与卵巢中的FSH相互作用，并决定对该激素的反应性。FSHR水平降低导致反应性差，并影响卵泡生成。在高加索人群中，多囊卵巢综合征（PCOS）患者更常见该基因的某些多态性。
α-链不活跃；生物特异性归因于β链。诱导卵巢Graafian卵泡成熟；促进雄性生殖细胞的发育；激活胞浆酪氨酸激酶。

一般描述

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH, hCG and TSH, which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.
 

应用

Follicle stimulating hormone from porcine pituitary has been used for the in vitro maturation, fertilization and co-culture of cumulus oocyte complex and the co-culture of primary germ and Sertoli cells obtained from adult rat testes.
 

生化/生理作用

FSH in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in this gene are more commonly found in patients with polycystic ovary syndrome (PCOS).
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
 

其他说明

Two-chain glycoprotein hormone
 

单位定义

One unit is the activity of 1 mg of Armour FSH Standard G-94 by the method of Steelman, S.L., and Pohley, F.M., Endocrinology, 53, 604 (1953).
 
 

属性

形式

powder

质量水平

200

包装

pkg of 50 unit per vial

technique(s)

cell culture | mammalian: suitable

溶解性

H2O: soluble 50 mg/mL

UniProt登记号

P01228
P23945

储存温度

2-8°C

InChI

1S/C79H125N19O23S/c1-39(2)34-53(90-67(110)51(27-29-57(102)103)87-66(109)49(20-14-15-31-80)86-70(113)54(35-45-18-12-11-13-19-45)92-76(119)63(43(9)99)96-65(108)48(81)38-122)72(115)93-60(40(3)4)75(118)91-55(36-46-23-25-47(101)26-24-46)71(114)88-52(28-30-58(104)105)69(112)97-64(44(10)100)77(120)94-61(41(5)6)74(117)89-50(21-16-32-84-79(82)83)68(111)95-62(42(7)8)78(121)98-33-17-22-56(98)73(116)85-37-59(106)107/h11-13,18-19,23-26,39-44,48-56,60-64,99-101,122H,14-17,20-22,27-38,80-81H2,1-10H3,(H,85,116)(H,86,113)(H,87,109)(H,88,114)(H,89,117)(H,90,110)(H,91,118)(H,92,119)(H,93,115)(H,94,120)(H,95,111)(H,96,108)(H,97,112)(H,102,103)(H,104,105)(H,106,107)(H4,82,83,84)/t43-,44-,48+,49+,50+,51+,52+,53+,54+,55+,56+,60+,61+,62+,63+,64+/m1/s1

InChI key

RPJRYFRWJUYJGY-AYWRSWFDSA-N

Gene Information

human ... FSHR(2492)
pig ... FSHB(396895)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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