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佛手柑素,Bergamottin;analytical standard, ≥98.0% (HPLC)

别名:香柠檬亭;香柠檬素;Bergamotine;Bergaptin; Empirical Formula (Hill Notation): C21H22O4 CAS号: 7380-40-7 分子量: 338.40 Beilstein: 1353914 MDL编号: MFCD00017409 PubChem化学物质编号: 329747253 NACRES: NA.24
货号(SKU): 01338
CAS号: 7380-40-7
MDL号: MFCD00017409
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¥2,113.54

说明

佛手柑属呋喃香豆素家族的一员,主要存在于葡萄柚汁中。 据报道,它是一种新型的信号转导和转录 3 (STAT3) 抑制剂的激活剂。 它是一种已知的细胞色素 P450 34A 药物抑制剂,还具有多种抗肿瘤和抗炎活性。

佛手柑可用作分析标准品,以测试其在以下方面的功效:
肿瘤细胞中 STAT3 激活通路的阻断剂; 研究了它在治疗多发性骨髓瘤 (MM) 和其他癌症方面的潜力。
通过抑制 NF-kB 信号通路及其调节基因产物来预防和治疗癌症。

一般描述

Bergamottin, a member of the furanocoumarin family, is primarily found in grapefruit juice. It is reported to be a novel signal transducer and activator of the transcription 3 (STAT3) inhibitor. It is a known drug inhibitor of cytochrome P450 34A and also exhibits diverse anti-tumor and anti-inflammatory activities.
 

应用

Bergamottin may be used as an analytical standard to test its efficacy in the following:
  • Blocker of STAT3 activation pathway in tumor cells; its potential in the therapy of multiple myeloma (MM) and other cancers is investigated.
  • Prevention and the treatment of cancer via suppression of the NF-kB signaling pathway and its regulated gene products.

 

属性

等级

analytical standard

质量水平

100

测定

≥98.0% (HPLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

75-80 °C

application(s)

food and beverages

格式

neat

储存温度

2-8°C

SMILES string

C\C(C)=C\CC\C(C)=C\COc1c2C=CC(=O)Oc2cc3occc13

InChI

1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+

InChI key

DBMJZOMNXBSRED-OQLLNIDSSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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