sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

XCT790,≥98% (HPLC), solid

别名:XCT-790;XCT 790;3-[4-(2,4-双-三氟甲基苄氧基)-3-甲氧基苯基]-2-氰基-N-(5-三氟甲基-1,3,4-噻二唑-2-基)丙烯酰胺;3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide

CAS号 725247-18-7 经验分子式(希尔表示法) C23H13F9N4O3S 分子量 596.42 MDL number MFCD08277031 PubChem Substance ID 24724669 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): X4753
CAS号: 725247-18-7
MDL号: MFCD08277031
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥2,185.14

产品描述

Application

XCT790 has been used:
• as an estrogen-related receptor (ERR)α inverse agonist in C2C12 myotubes[10]
• as an estrogen-related receptor (ERR)α inverse agonist to elucidate decidualization functionality of ERRα in endometrial embryonic stem cells[6]
• as an autophagy inducer in human neuroblastoma SH-SY5Y and HeLa cell lines. [8]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

XCT 790 is a 5′adenosine monophosphate-activated protein kinase (AMPK) activator. It also acts as a proton ionophore and an uncoupler of oxidative phosphorylation in mitochondria. XCT790 impairs vascular endothelial growth factor (VEGF) and angiopoietin 2 (Ang-2) expression and exhibits suppression of endometrial tumor via estrogen-related receptor (ERRα) inhibition. XCT790 mediates cell cycle arrest and favors apoptosis in triple-negative breast cancer (TNBC).

XCT790 是一种强效、特异性的 ERRα 反向激动剂。XCT790 具有选择性,在浓度低于 10 μM 时,对相关核受体(如 ERRγ 或 ERα)无明显拮抗活性。在使用 GAL4-ERR LBD 或全长 ERR 和 mSHP 启动子的瞬时转染试验中,IC 50 值为 300-500 nM。

Features and Benefits

该化合物也可通过 Sigma 药理活性化合物库 (LOPAC®1280) 查询。LOPAC 是一个生物学注释的高品质、即时筛选化合物的集合库。 点击这里了解更多信息。

法律信息

LOPAC 为以下机构的注册商标: Sigma-Aldrich Co. LLC

性质

Quality Level  100
assay  ≥98% (HPLC)
form  solid
color  yellow
solubility  DMSO: ≥10 mg/mL
storage temp.  2-8°C
SMILES string  COc1cc(ccc1OCc2ccc(cc2C(F)(F)F)C(F)(F)F)\C=C(/C#N)C(=O)Nc3nnc(s3)C(F)(F)F
InChI  1S/C23H13F9N4O3S/c1-38-17-7-11(6-13(9-33)18(37)34-20-36-35-19(40-20)23(30,31)32)2-5-16(17)39-10-12-3-4-14(21(24,25)26)8-15(12)22(27,28)29/h2-8H,10H2,1H3,(H,34,36,37)/b13-6+
InChI key  HQFNFOOGGLSBBT-AWNIVKPZSA-N


安全信息

危害声明 H413
个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10