sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

XAV939,≥98% (HPLC)

别名:3,5,7,8-四氢-2-[4-(三氟甲基)苯基]-4H-噻喃并[4,3-d]嘧啶-4-酮;3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

CAS号 284028-89-3 经验分子式(希尔表示法) C14H11F3N2OS 分子量 312.31 MDL number MFCD16879017 PubChem Substance ID 329830802 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): X3004
CAS号: 284028-89-3
MDL号: MFCD16879017
增值税发票 √ 免费送货 √ 订货电话:010-68689484
£93.19

产品描述

Application

XAV939 has been used in the inhibition
•  of tankyrase in neuroblastoma cell lines[3]
•  of diphtheria toxin-like ADP-ribosyltransferases (ARTD) in medulloblastoma cells[4]
•  of wnt signalling in human induced pluripotent stem cells (hiPSCs)[5]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

XAV939 is a cell-permeable dihydrothiopyranopyrimidinol,[1] which elicits anti-tumor functionality against colon, lung, breast and liver cancer.[2] It binds to catalytic poly-ADP-ribose polymerase (PARP) domain of the tankyrase enzyme resulting in β-catenin destruction. It also inhibits tankyrase in neuroblastoma promoting apoptosis in tumor cells.[3]

XAV939是一种端锚聚合酶抑制剂(从而抑制Wnt/β-连环蛋白信号转导)

Features and Benefits

该化合物是基因调控研究的推荐产品。点击这里 发现更多精选基因调控产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm

Other Notes

XAV939已经过Chemical Probes Portal的专业评审和推荐。有关更多信息,请访问Chemical Probes Portal网站上 XAV939探测摘要 页面。

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 5 mg/mL, clear
storage temp.  room temp
SMILES string  FC(F)(F)c1ccc(cc1)C2=NC3=C(CSCC3)C(=O)N2
InChI  1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20)
InChI key  KLGQSVMIPOVQAX-UHFFFAOYSA-N


安全信息

危害码 (欧洲) T
风险声明 (欧洲) 25-36
安全声明 (欧洲) 26-45
RIDADR UN 2811 6.1 / PGIII
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16