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WH-4-023,≥98% (HPLC)

别名:KIN112;2,6-Dimethylphenyl N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate;(2,4-二甲氧基苯基)(2-((4-(4-甲基哌嗪-1-基)苯基)氨基)嘧啶-4-基)氨基甲酸-2,6-二甲基苯酯

CAS号 837422-57-8 经验分子式(希尔表示法) C32H36N6O4 分子量 568.67 MDL number MFCD28138072 PubChem Substance ID 329825792 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1334
CAS号: 837422-57-8
MDL号: MFCD28138072
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¥24,538

产品描述

一种强效的和有选择性的酪氨酸激酶(LCK)和Src抑制剂。IC50分别是2 nm和6 nm。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).

WH-4-023 belongs to the Src kinase family.[2] It stimulates apoptosis in GC-resistant T-acute lymphoblastic leukemia (T-ALL) cells.[1]

Other Notes

WH-4-023 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the WH-4-023 probe summary on the Chemical Probes Portal website.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 20 mg/mL, clear
storage temp.  −20°C
SMILES string  CN1CCN(C2=CC=C(NC3=NC=CC(N(C4=CC=C(OC)C=C4OC)C(OC5=C(C)C=CC=C5C)=O)=N3)C=C2)CC1
InChI  1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35)
InChI key  NBTNHSGBRGTFJS-UHFFFAOYSA-N


安全信息

符号 
GHS06  GHS06
信号词 Danger
危害声明 H301
警示性声明 P301 + P310 + P330
RIDADR UN 2811 6.1 / PGIII
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10