5, 25 mg in glass bottle
WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).
WH-4-023 belongs to the Src kinase family. It stimulates apoptosis in GC-resistant T-acute lymphoblastic leukemia (T-ALL) cells.
WH-4-023 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the WH-4-023 probe summary on the Chemical Probes Portal website.
|Quality Level ||100|
|assay ||≥98% (HPLC)|
|color ||white to beige|
|solubility ||DMSO: 20 mg/mL, clear|
|storage temp. ||−20°C|
|SMILES string ||CN1CCN(C2=CC=C(NC3=NC=CC(N(C4=CC=C(OC)C=C4OC)C(OC5=C(C)C=CC=C5C)=O)=N3)C=C2)CC1|
|InChI key ||NBTNHSGBRGTFJS-UHFFFAOYSA-N|
RIDADR UN 2811 6.1 / PGIII