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UNC0642,≥98% (HPLC)

别名:2-(4,4-二氟哌啶-1-基)-6-甲氧基-N-[1-(丙-2-基)哌啶-4-基]-7-[3-(吡咯烷-1-基)丙氧基 ]喹唑啉-4-胺;2-(4,4-Difluoropiperidin-1-yl)-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine

Empirical Formula (Hill Notation): C29H44F2N6O2 分子量: 546.70 MDL编号: MFCD28044322 PubChem化学物质编号: 329825635 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1037
CAS号: 1481677-78-4
MDL号: MFCD28044322
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$441.47

说明

应用

UNC0642 has been used to treat human HeLa cells to inhibit the DNA ligase 1 (LIG1) /UHRF1 (ubiquitin-like with PHD and ring finger domains 1) interaction.
UNC0642 已用于治疗人类 HeLa 细胞,以抑制 DNA 连接酶 1 (LIG1) /UHRF1(泛素样与 PHD 和无名指结构域 1)相互作用。
 

包装

5, 25 mg in glass bottle
 

生化/生理作用

UNC0642 is a potent, selective inhibitor of histone methyltransferases G9a (EHMT2) and GLP (EHMT1), which catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9), and other non-histone substrates such as p53 and WIZ. UNC0642 has an in vitro IC50 <15 nM with greater than 100-fold selectivity over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC0642 has the same potency with improved PK properties relative to UNC0638, which should make it a more useful probe in an in vivo setting. For full characterization details, please visit the UNC0642 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit
 

特点和优势

UNC0642 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

其他说明

UNC0642 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the UNC0642 probe summary on the Chemical Probes Portal website.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear (warmed)

储存温度

2-8°C

SMILES string

FC(CC1)(F)CCN1C2=NC(NC3CCN(C(C)C)CC3)=C4C(C=C(OCCCN5CCCC5)C(OC)=C4)=N2

InChI

1S/C29H44F2N6O2/c1-21(2)36-14-7-22(8-15-36)32-27-23-19-25(38-3)26(39-18-6-13-35-11-4-5-12-35)20-24(23)33-28(34-27)37-16-9-29(30,31)10-17-37/h19-22H,4-18H2,1-3H3,(H,32,33,34)

InChI key

RNAMYOYQYRYFQY-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16