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UK-78282 monohydrochloride,≥98% (HPLC)

别名:UK78282单盐酸盐;4-[(二苯基甲氧基)甲基]-1-[3-(4-甲氧基苯基)丙基]-哌啶单盐酸盐;4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride

Empirical Formula (Hill Notation): C29H35NO2HCl CAS号: 136647-02-4 分子量: 466.05 MDL编号: MFCD16875438 PubChem化学物质编号: 329827628 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): U3885
CAS号: 136647-02-4
MDL号: MFCD16875438
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$354.80

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
 
UK-78282 阻止 Kv1.3 和 Kv1.4。 Kv1.3 和 Kv1.4 是电压门控钾通道的 Shaker 家族成员。 Kv1.3 在大脑和效应记忆 T (Tem) 细胞中表达,Kv1.4 在大脑中表达。 两个通道都参与设置神经元的膜电位。 此外,Kv1.3 维持 T 记忆细胞的膜电位,并在 T 细胞活化时上调,导致多种免疫过程和疾病。 长期以来,人们一直在寻找 Kv1.3 的阻滞剂以提供治疗益处,它们也是研究免疫系统的宝贵工具。 需要 Kv1.4 的选择性阻止程序,因为目前可用的程序很少。 UK-78282 对免疫系统研究很有价值,其中 Kv1.4 的缺失使其在功能上对 Kv1.3 具有选择性,并且显示出对 T 细胞活化的抑制。 UK-78282对于Kv1.4功能的研究也是有价值的。
 

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

制备说明

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

储存条件

desiccated

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

创始人

Pfizer

运输

wet ice

储存温度

−20°C

SMILES string

Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1

InChI

1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H

InChI key

ZZSQARULZYQMIG-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation markEnvironment

警示用语:

Warning

危险声明

预防措施声明

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16