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UK-371804 HCl,≥98% (HPLC)

别名:UK371804;2-(((4-Chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride, N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride, UK-371804 HCl

CAS号 256476-36-5 经验分子式(希尔表示法) C14H16ClN5O4S · HCl 分子量 422.29 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0344
CAS号: 256476-36-5
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$227.77

产品描述

Biochem/physiol Actions

UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.

UK-371,804是一种可逆的,底物竞争性,高效(Ki = 10 nM)和选择性尿激酶型纤溶酶原激活剂(uPA)抑制剂,对tPA,纤溶酶,因子IXa和Xa的选择性极好。 当局部使用时,UK-371,80有效渗透到实验猪的切除伤口中,而对伤口闭合没有不利影响。 UK-371,804即使在存在组织蛋白的情况下,也能有效阻止EGR-FMK与人uPA结合。

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

法律信息

Pfizer is a registered trademark of Pfizer, Inc.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
mfr. no.  Pfizer®
color  white to beige
solubility  DMSO: 10 mg/mL, clear (warmed)
originator  Pfizer
shipped in  dry ice
storage temp.  −20°C
SMILES string  CC(C)(NS(=O)(C1=CC2=C(C=C1)C(Cl)=CN=C2NC(N)=N)=O)C(O)=O.[H]Cl


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16