UK-356618，≥98% (HPLC)

图片 UK-356618，≥98% (HPLC)
别名：UK356618；(2R)-N1-(1S)-2,2-Dimethyl-1-({(1R)-1-phenylethylamino}carbonyl)propyl-2-{3-(3-methyl-4-phenyl)-phenylpropyl}-(N4-hydroxy)butanediamide, UK-356,618

Empirical Formula (Hill Notation): C34H43N3O4 CAS号: 230961-08-7 分子量: 557.72 MDL编号: MFCD19443865 PubChem化学物质编号: 329823737 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0152
CAS号: 230961-08-7
MDL号: MFCD19443865
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¥1,688.20

说明

应用

UK-356618 has been used as a specific matrix metalloproteinase 3 (MMP3) inhibitor to study its effect on amitriptyline-induced glial cell line-derived neurotrophic factor (GDNF) mRNA expression and to confirm its influence on amitriptyline-induced zymographic MMP-9 activation in rat C6 astroglial cells.[1]
 

生化/生理作用

UK 356618 has the potential to inhibit interleukin (IL)-6-induced cell migration in NCI H446 small cell lung cancer cells in vitro.[2]
UK-356,618 is a potent, selective inhibitor of Matrix metalloproteinase MMP3 (stromelysin-1). MMP-3 IC50 = 5.9 nM, selectivity is 140-fold vs MMP-1, -2, -9, and -14.
 

其他说明

This compound was developed by Pfizer for Cytoskeleton & Extracellular Matrix research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

测定

≥98% (HPLC)

形式

powder

旋光性

α/D >+25.0°, c = 0.5 in methanol

mfr. no.

Pfizer®

颜色

white to tan

溶解性

DMSO: ≥25 mg/mL

创始人

Pfizer

储存温度

2-8°C

SMILES string

CC@@H(NC(=O)C@@H(NC(=O)C@H(CCCc1ccc(c(C)c1)-c2ccccc2)CC(=O)NO)C(C)(C)C)c3ccccc3

InChI

1S/C34H43N3O4/c1-23-21-25(19-20-29(23)27-16-10-7-11-17-27)13-12-18-28(22-30(38)37-41)32(39)36-31(34(3,4)5)33(40)35-24(2)26-14-8-6-9-15-26/h6-11,14-17,19-21,24,28,31,41H,12-13,18,22H2,1-5H3,(H,35,40)(H,36,39)(H,37,38)/t24-,28-,31-/m1/s1

InChI key

JJHRUUKMPWUYIB-HVOSOHGQSA-N

 

安全信息

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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