TWEAK Receptor human，[FGF-inducible 14, TNFRSF12A]；recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell′s apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

 

TWEAKR belongs to the TNFR superfamily of transmembrane proteins and contains a cytoplasmic "death domain," which can activated the cell′s apoptotic machinery. Recombinant soluble TWEAKR is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAKR protein

 

EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

 

Lyophilized from 10 mM Sodium Phosphate, pH 7.5 + 50 mM NaCl.

 

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.