TrKA磷酸化抑制剂，Tyrphostin AG 879；99% (HPLC)

图片 TrKA磷酸化抑制剂，Tyrphostin AG 879；99% (HPLC)
别名：一种酪氨酸磷酸化抑制剂；α-氰基-（3,5-二叔丁基-4-羟基）硫辛酰胺；α-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide；Tyrphostin AG879

Empirical Formula (Hill Notation): C18H24N2OS CAS号: 148741-30-4 分子量: 316.46 MDL编号: MFCD00236450 PubChem化学物质编号: 24278728 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: T2067
CAS号: 148741-30-4
MDL号: MFCD00236450
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说明

应用

Tyrphostin AG 879 (AG879) has been used for studying its effect on ErbB2 receptor phosphorylation in A431 cells. This study reported that AG879 at 10 muM can cause 15% inhibition of receptor phosphorylation1. AG879 has also been used as a neurotrophic tyrosine kinase receptor inhibitor to study the disruption of Sertoli cell aggregation2.
 

生化/生理作用

Tyrphostin AG 879 is known to block RAF-1 and Her-2 expression and exhibit anticancer functions in breast cancer cells3. Furthermore, AG879 is known to block ETK1-PAK1 interactions and the growth of RAS-induced sarcomas in nude mice4.
Inhibits the tyrosine kinase activity of the nerve growth factor receptor (TrkA; pp140trk) and heregulin receptor erbB-2 (HER-2).
 

特点和优势

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 

制备说明

Tyrphostin AG 879 is soluble in DMSO at 26/ml and is insoluble in water.
 
 

属性

质量水平

100

测定

99% (HPLC)

溶解性

DMSO: soluble (at 26 mg/ml)
H2O: insoluble

SMILES string

CC(C)(C)c1cc(\C=C(/C#N)C(N)=S)cc(c1O)C(C)(C)C

InChI

1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,21H,1-6H3,(H2,20,22)/b12-7+

InChI key

XRZYELWZLNAXGE-KPKJPENVSA-N

Gene Information

human ... ERBB2(2064) , NTRK1(4914)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

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