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TH-257,≥98% (HPLC)

别名:N-丁基-4-[(苯基氨基)磺酰基]-N-(苯基甲基)苯甲酰胺,N-苄基-N-丁基-4-(N-苯基氨磺酰基)苯甲酰胺;N-Butyl-4-[(phenylamino)sulfonyl]-N-(phenylmethyl)benzamide, N-Benzyl-N-butyl-4-(N-phenylsulfamoyl)benzamide

Empirical Formula (Hill Notation): C24H26N2O3S 分子量: 422.54
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2275
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$175.50

说明

生化/生理作用

TH-257 is a potent, type III allosteric LIM-kinase (LIMK1 & LIMK2) inhibitor (LIMK1/2 IC50 in nM = 48/29 by cell-free kinase assay and 250/150 by live cell NanoBRET assay using respective transfectants) that targets LIMK1/2 DFG-out conformation in a non-ATP-competitive manner and exhibits no significant off-target activity by KINOMEscan assay at 1 μM. TH-263 is a structure analog and the recommended negative control for TH-257. For characterization details of TH-257, please visit the TH-257 probe summary on the Structural Genomics Consortium (SGC) website.

TH-263 is the negative control for the active probe, TH-257. TH-263 is available from Sigma. To learn more about and purchase TH-263,
 
TH-257 是一种有效的 III 型变构 LIM 激酶(LIMK1 和 LIMK2)抑制剂(LIMK1/2 IC50 innM = 48/29 通过无细胞激酶测定和 250/150 通过使用相应转染子的活细胞 NanoBRET 测定), 以非 ATP 竞争性方式靶向 LIMK1/2 DFG-out 构象,并且在 1 μM 下通过 KINOMEscan 测定没有显示出显着的脱靶活性。 TH-263 是一种结构类似物,推荐用于 TH-257 的阴性对照。
 

特点和优势

TH-257 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
 

属性

测定

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES string

O=C(C1=CC=C(C=C1)S(NC2=CC=CC=C2)(=O)=O)N(CC3=CC=CC=C3)CCCC

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16