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STK16-IN-1,≥98% (HPLC)

别名:1-(4-氟-3-甲基苯基)-1H-吡咯[2,3-h][1,6]萘啶-2(6H)-酮;STK16IN1;1-(4-Fluoro-3-methylphenyl)-1,7-dihydro-2H-pyrrolo[2,3-h]-1,6-naphthyridin-2-one, 1-(4-Fluoro-3-methylphenyl)-1H-pyrrolo[2,3-h][1,6]naphthyridin-2(7H)-one

CAS号 1223001-53-3 经验分子式(希尔表示法) C17H12FN3O 分子量 293.30 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML1728
CAS号: 1223001-53-3
MDL号: MFCD30491884
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¥1,164.07

产品描述

一种高度选择性和具有ATP竞争性的STK16激酶抑制剂。

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

STK16-IN-1 is a cell-permeable pyrrolonaphthyridinone compound that acts as an ATP-competitive inhibitor against NAK (Numb Associated Kinase) family serine/threonine kinase STK16 (IC50/substrate = 0.91 μM/4EBP1 and 1.2 μM/DRG1, [ATP] = 20 μM) with excellent selectivity over a panel of 378 kinases. Despite its inhibitory potency against PI 3-Ks (IC50 = 1.07, 0.856, 0.867 μM against p110α/p85α, p110σ/p85α, p110γ , respectively) in cell-free assays, STK16-IN-1 is ineffective against their cellular activity up to 10 μM concentration. STK16-IN-1 treatment (10 μM for 72 hrs) is shown to cause cell number reduction (~50% in HCT-116 and MCF-7 cultures), as well as increased populations of binucleated cells (~5-fold in MCF-7 culture) and G2/M cells (~7 and 3-fold in HCT-116 and MCF-7 cultures, respectively) in an STK16-dependent manner. A useful tool for elucidating STK16 biological functions.

性质

Quality Level  100
assay  ≥98% (HPLC)
form  powder
storage condition  protect from light
color  white to beige
solubility  DMSO: 10 mg/mL, clear (warmed)
storage temp.  2-8°C
SMILES string  CC1=CC(N2C(C(C=CN3)=C3N=C4)=C4C=CC2=O)=CC=C1F


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H315 - H319
警示性声明 P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32