SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity.
[3] It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.
[4]SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor.