2-(3,5-二叔丁基-4-羟基苯基)乙烯基-1,1-二膦酸四乙酯，SR 12813，≥98%, solid

图片 2-(3,5-二叔丁基-4-羟基苯基)乙烯基-1,1-二膦酸四乙酯，SR 12813，≥98%, solid
别名：SR12813；2-(3,5-二叔丁基-4-羟基苯基)乙烯基-1,1-二膦酸四乙酯；Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate

Empirical Formula (Hill Notation): C24H42O7P2 CAS号: 126411-39-0 分子量: 504.53 MDL编号: MFCD00888473 PubChem化学物质编号: 329824541 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: S4194
CAS号: 126411-39-0
MDL号: MFCD00888473
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说明

SR-12813用作HepG2肝癌细胞中孕烷X受体（PXR）结合测定和人肝细胞中脱氢表雄酮介导的PXR活化测定的对照。
SR-12813是一种1，1-双膦酸酯，具有低胆固醇血症活性。它通过增强HMG-CoA还原酶的降解来减少胆固醇的生物合成。
SR 12813是一种孕烷X受体（PXR，NR 112）激动剂;降胆固醇药;HMGCoA还原酶抑制剂。

应用

SR-12813 was used as control in pregnane X receptor (PXR) binding assay performed in HepG2 liver carcinoma cells[1] and PXR-activation assay mediated by dehydroepiandrosterone in human hepatocytes.[2]
 

生化/生理作用

SR-12813 is a 1,1-bisphosphonate ester that exhibits hypocholesterolemic activity.[3] It decreases the biosynthesis of cholesterol by enhancing the degradation of HMG-CoA reductase.[4]
SR 12813 is a pregnane X receptor (PXR, NR 112) agonist; cholesterol lowering drug; HMGCoA reductase inhibitor.
 

特点和优势

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

生物来源

synthetic (organic)

质量水平

100

测定

≥98%

形式

solid

溶解性

DMSO: ≥10 mg/mL
H2O: insoluble

创始人

GlaxoSmithKline

SMILES string

CCOP(=O)(OCC)C(=C/c1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C)\P(=O)(OCC)OCC

InChI

1S/C24H42O7P2/c1-11-28-32(26,29-12-2)21(33(27,30-13-3)31-14-4)17-18-15-19(23(5,6)7)22(25)20(16-18)24(8,9)10/h15-17,25H,11-14H2,1-10H3

InChI key

YQLJDECYQDRSBI-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

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