SB939 [Pracinostat]；≥99% (HPLC)

Application

一种有效的pan-HDAC抑制剂。

SB939 is a potent inhibitor of HDAC class I and II isoenzymes, HDAC1, HDAC2, HDAC3 HDAC4, HDAC5, HDAC7, HDAC8, HDAC9 and HDAC10 with the IC50 values ranging from 43 nM to 140 nM. HDAC6 shows an IC50 of 1008 nM. It markedly inhibits HDAC11 of the HDAC class IV enzymes with an IC50 of 93 nM. SB939 shows significant anti-proliferative activity against a wide variety of tumor cell lines, especially Leukemia cells and cutaneous T-cell Lymphoma cells with IC50 values ranging from 50 nM (H9 cells) to 170 nM (HEL92.1.7 cells).

SB939是HDAC I和II类同功酶HDAC1，HDAC2，HDAC3，HDAC4，HDAC5，HDAC7，HDAC8，HDAC9和HDAC10的有效抑制剂，IC50值范围为43 nM至140 nM。 HDAC6的IC50为1008 nM。 它显着抑制HDAC IV类酶的HDAC11，IC50为93 nM。 SB939对多种肿瘤细胞系（尤其是白血病细胞和皮肤T细胞淋巴瘤细胞）表现出显着的抗增殖活性，IC50值范围从50 nM（H9细胞）到170 nM（HEL92.1.7细胞）。

性质

安全信息

符号 

  GHS07

信号词 Warning

危害声明 H302

警示性声明 P301 + P312 + P330

RIDADR NONH for all modes of transport

WGK德国 WGK 3