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SB-366791,≥98% (HPLC), powder

别名:SB366791;SB 366791;N-(3-Methoxyphenyl)-4-chlorocinnamide;3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺

CAS号 472981-92-3 经验分子式(希尔表示法) C16H14NO2Cl 分子量 287.74 MDL number MFCD01033818 PubChem Substance ID 24278690 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): S0441
CAS号: 472981-92-3
MDL号: MFCD01033818
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¥2,009.80

产品描述

一种有效且选择性的TRPV1(辣椒素受体)拮抗剂,IC50:5.7nM。

Application

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:
• to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)[2]
• to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity[3]
• to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)[10]

包装

5 mg in glass bottle

Biochem/physiol Actions

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.[1]

Vanilloid receptor-1 (TRPV1) antagonist.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

性质

assay  ≥98% (HPLC)
form  powder
color  white to beige
solubility  DMSO: 5 mg/mL, clear
originator  GlaxoSmithKline
SMILES string  COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
InChI  1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
InChI key  RYAMDQKWNKKFHD-JXMROGBWSA-N
Gene Information  human ... TRPV1(7442)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16