SB-366791；≥98% (HPLC), powder

图片 SB-366791；≥98% (HPLC), powder
别名：SB366791；SB 366791；3-(4-氯苯基)-N-(3-甲氧基苯基)-2-丙烯酰胺；N-(3-Methoxyphenyl)-4-chlorocinnamide

Empirical Formula (Hill Notation): C16H14NO2Cl CAS号: 472981-92-3 分子量: 287.74 MDL编号: MFCD01033818 PubChem化学物质编号: 24278690 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: S0441
CAS号: 472981-92-3
MDL号: MFCD01033818
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¥2,354.84

说明

应用

SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:
  • to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)[1]
  • to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity[2]
  • to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)[3]

生化/生理作用

SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.[4]
Vanilloid receptor-1 (TRPV1) antagonist.
 

特点和优势

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 
 

属性

检测方案

≥98% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 5 mg/mL, clear

创始人

GlaxoSmithKline

SMILES string

COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1

InChI

1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+

InChI key

RYAMDQKWNKKFHD-JXMROGBWSA-N

Gene Information

human ... TRPV1(7442)

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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