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SB-222200,≥98% (HPLC), solid

别名:SB222200;SB 222200;(S)-3-甲基-2-苯基-N-(1-苯基丙基)-4-喹啉甲酰胺;(S)-3-Methyl-2-phenyl-N-(1-phenylpropyl)-4-quinolinecarboxamide

Empirical Formula (Hill Notation): C26H24N2O CAS号: 174635-69-9 分子量: 380.48 MDL编号: MFCD00944072 PubChem化学物质编号: 24278254 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): S5192
CAS号: 174635-69-9
MDL号: MFCD00944072
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$549.80

说明

应用

The pharmacodynamics profile of SB 222200 enables its use as a tool to study physiological and pathophysiological roles of NK-3 receptor in CNS-modulated behaviors.
 
SB222200的药效学特征使其可用作研究 NK-3 受体在 CNS 调节行为中的生理和病理生理作用的工具。 SB 222200 是一种 2-苯基-4-喹啉甲酰胺,是一种选择性、可逆和竞争性的人类 NK-3 受体拮抗剂,可有效穿过血脑屏障。 它抑制有意识的兔子 NK-3 受体诱导的瞳孔缩小或瞳孔收缩。 非肽类 NK3 速激肽受体拮抗剂。
 

包装

10, 50 mg in glass bottle
 

生化/生理作用

SB 222200 is a 2-phenyl-4-quinolinecarboxamides and a selective, reversible and competitive antagonist of human NK-3 receptor that effectively crosses the blood-brain barrier. It inhibits the NK-3 receptor-induced miosis or pupil constriction in conscious rabbits.1,2
Non-peptide NK3 tachykinin receptor antagonist.
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
 

法律信息

Sold for research purposes under agreement from Glaxo­Smith­Kline
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

solid

颜色

light yellow

溶解性

DMSO: soluble ~28 mg/mL
H2O: insoluble

创始人

GlaxoSmithKline

储存温度

2-8°C

SMILES string

CC[C@H](NC(=O)c1c(C)c(nc2ccccc12)-c3ccccc3)c4ccccc4

InChI

1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1

InChI key

MQNYRKWJSMQECI-QFIPXVFZSA-N

Gene Information

human ... TACR2(6865), TACR3(6870)

 

安全信息

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16