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SAR407899 free base,≥99%

别名:6-(4-哌啶基氧基)-1(2H)-异喹啉酮;6-(piperidin-4-yloxy)isoquinolin-1(2H)-one

CAS:923359-38-0;分子式:C14H16N2O2;分子量:244.29
制造商品牌: BSZH 科学公司
货号(SKU): S06094
CAS号: 923359-38-0
MDL号: MFCD28335199
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥1,550.00

产品描述

产品可溶于DMSO(6mg/mL 加热)

Application

一种具有选择性和抗高血压活性的Rho激酶抑制剂。

SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. SAR407899 is equipotent against human and rat-derived Rho-kinase 2 with inhibition constant values of 36 nM and 41 nM, respectively. SAR407899 is approximately 8-fold more active than fasudil. SAR407899 potently (mean IC(50) values: 122 to 280 nM) and species-independently relaxed precontracted isolated arteries of different species and different vascular beds. The antihypertensive effect of SAR407899 was superior to that of fasudil and Y-27632.

SAR407899有效抑制内皮素1诱导的肾抵抗性动脉收缩。 SAR407899与人和大鼠的Rho激酶2等价,抑制常数分别为36 nM和41 nM。 SAR407899的活性比法舒地尔高约8倍。 SAR407899有效(平均IC(50)值:122至280 nM)和独立于物种的不同物种和不同血管床的预收缩孤立动脉。 SAR407899的抗高血压作用优于法舒地尔和Y-27632。

性质

Iupac Name6-(piperidin-4-yloxy)isoquinolin-1-ol
Inchi Code1S/C14H16N2O2/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11/h1-3,8-9,11,15H,4-7H2,(H,16,17)
Inchi KeyIPEXHQGMTHOKQV-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32