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RS-1,≥98% (HPLC)

别名:RAD51 刺激性化合物 1, 3-[(苄基氨基)磺酰基]-4-溴-N-(4-溴苯基)苯甲酰胺, 4-溴-N-(4-溴苯基)-3 - [[(苯基甲基)氨基]磺酰基]-苯甲酰胺;4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide, RAD51-stimulatory compound 1, 3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benzamide

Empirical Formula (Hill Notation): C20H16Br2N2O3S CAS号: 312756-74-4 分子量: 524.23 MDL编号: MFCD00348720 PubChem化学物质编号: 329824048 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): R9782
CAS号: 312756-74-4
MDL号: MFCD00348720
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€150.80

说明

应用

RS-1 has been shown to enhance CRISPR genome editing efficiency. To see other small molecule CRISPR enhancers, visit sigma.com/CRISPR-enhancers.
RS-1 has been used:
  • as a homology-directed repair (HDR) agonist to study its effects on in human hematopoietic stem/progenitor cells (HSPCs)
  • as HDR agonist to analyze its effects on DNA repair modulation in human induced pluripotent stem (iPS) cells
  • as RAD51 agonist to study its effects on double-stranded break repair

包装

5, 25 mg in glass bottle
 

生化/生理作用

RS-1(RAD51-刺激性化合物1)是人同源重组(HR)蛋白 RAD51 的刺激物。RS-1 刺激 hRAD51 与单链 DNA(ssDNA)的结合,并且在不抑制 hRAD51 ATP 酶活性的情况下,通过稳定 hRAD51 微丝的活性形式来增强重组活性。研究表明,RS-1 可增强 HEK293A 细胞中 CRISPR-Cas9 的敲入效率,并且在兔中,它可以提高 TALEN 和 cas9 介导的敲入效率。
RS-1 is a sulfonamido-benzamide compound.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

off-white to light tan

溶解性

DMSO: ≥10 mg/mL

储存温度

room temp

SMILES string

Brc1ccc(NC(=O)c2ccc(Br)c(c2)S(=O)(=O)NCc3ccccc3)cc1

InChI

1S/C20H16Br2N2O3S/c21-16-7-9-17(10-8-16)24-20(25)15-6-11-18(22)19(12-15)28(26,27)23-13-14-4-2-1-3-5-14/h1-12,23H,13H2,(H,24,25)

InChI key

SWKAVEUTKGKHSR-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

预防措施声明

RIDADR

NONH for all modes of transport

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16