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Ro25-6981马来酸盐,Ro 25-6981 maleate salt;≥98% (HPLC)

别名:1-哌啶丙醇;1-Piperidinepropanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-, ( αR,βS)-, (2Z)-2-butenedioate (1:1), [R-(R*,S*)]-α-(4-Hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol maleate salt
CAS号 1312991-76-6 经验分子式(希尔表示法) C22H29NO2 · C4H4O4 分子量 455.54 MDL number MFCD06798375 PubChem Substance ID 329825445 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0495
CAS号: 1312991-76-6
MDL号: MFCD06798375
增值税发票 √ 免费送货 √ 订货电话:010-68689484
HK$1,883.44

产品描述

Application

Ro 25-6981 maleate salt has been used as a selective N-methyl D-aspartate receptor subtype 2B (NR2B) blocker to study its effects on patch-clamp recordings of N-methyl D-aspartate receptor subtype 2A (NR2A)-containing N-methyl D-aspartate receptor (NMDAR) excitatory postsynaptic currents (EPSCs).[1]

包装

5, 25 mg in glass bottle

Biochem/physiol Actions

Ro 25-6981 maleate salt is a potent and selective antagonist of NMDA glutamate receptors containing the NR2B subunit with IC50 values of .009 μM for NR2B vs. 52 μM for NR2A subunits. Ro 25-6981 has been shown to have neuroprotectant effects and to reduce inflammatory and neuropathic pain in rodent models.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

性质

Quality Level100
assay≥98% (HPLC)
formpowder
optical activity[α]/D +15 to +22°, c = 1 in methanol
storage conditiondesiccated
colorwhite to beige
solubilityH2O: 2 mg/mL (clear solution, warmed)
storage temp.2-8°C
SMILES stringOC(=O)\C=C/C(O)=O.C[C@@H](CN1CCC(CC1)Cc2ccccc2)[C@@H](O)c3ccc(O)cc3
InChI1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChI keyFYJZEHCQSUBZDY-SEELMCCHSA-N


安全信息

危害码 (欧洲) Xi,N
风险声明 (欧洲) 36/37/38-50
安全声明 (欧洲) 26-61
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 128 | 東京Tokyo ≥ 44 | 香港与北京 ≥ 16