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RITA,The p53 Activator III;≥97% (HPLC)

别名:NSC 652287;2,5双(5-羟甲基-2-噻吩基)呋喃;2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan;Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X, p53 Activator III, RITA

CAS号 213261-59-7 经验分子式(希尔表示法) C14H12O3S2 分子量 292.37
货号(SKU): 506149
CAS号: 213261-59-7
MDL号: MFCD03235294
增值税发票 √ 免费送货 √ 订货电话:010-68689484
$289.82

产品描述

General description

A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.

包装

1 mg in Plastic ampoule

Biochem/physiol Actions

Cell permeable: yes

Primary Target
p53

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Grinkevich, V., et al. 2005. Nat. Med.11, 1136.
Krajewski, M., et al. 2005. Nat. Med.11, 1135.
Issaeva, N., et al. 2004. Nat. Med.10, 1321.
Nieves-Neira, W., et al. 1999. Mol. Pharmacol.56, 478.
Rivera, M.I., et al. 1999. Biochem. Pharmacol.57, 1283.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

性质

Quality Level  100
assay  ≥97% (HPLC)
form  crystalline solid
mfr. no.  Calbiochem®
storage condition  OK to freeze
 protect from light
storage conditions  +2C to +8C
solubility  ethanol: 1 mg/mL
 DMSO: 3 mg/mL
shipped in  ambient
InChI  1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
InChI key  KZENBFUSKMWCJF-UHFFFAOYSA-N


安全信息

WGK德国 WGK 1
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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