R(+)-维拉帕米单盐酸盐水合物，R(+)-Verapamil monohydrochloride hydrate；≥98% (HPLC), powder

图片 R(+)-维拉帕米单盐酸盐水合物，R(+)-Verapamil monohydrochloride hydrate；≥98% (HPLC), powder
别名：盐酸维拉帕米水合物；R-维拉帕米盐酸盐；Empirical Formula (Hill Notation): C27H38N2O4 · HCl · xH2O CAS号: 38176-02-2 分子量: 491.06 (anhydrous basis) EC 号: 205-800-5 MDL编号: MFCD11046028 PubChem化学物质编号: 24900706 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: V106
CAS号: 38176-02-2
MDL号: MFCD11046028
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说明

应用

R(+)-Verapamil monohydrochloride hydrate has been used as a P-glycoprotein (gp) inhibitor, to detect P-gp expression on the SK-OV-3 and SK-OV-3/DDP cell surface by flow cytometry.[1] It has also been used as a calcium channel blocker, to evaluate its effect on doxorubicin (DOX) cytotoxicity.[2]
 

生化/生理作用

Verapamil is a calcium channel blocker.[3] Verapamil hydrochloride is a phenyl-alkyl amine derivative and is potentially used for treating hypertension, angina pectoris and arrhythmias.[4] It is water soluble in nature.[4]
Inhibitor of P-glycoprotein; less active enantiomer of (±)-verapamil.
 

注意

hygroscopic
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]22/D +9.6°, c = 0.5 in ethanol(lit.)

储存条件

desiccated

颜色

white

溶解性

H2O: >30 mg/mL
ethanol: soluble

SMILES string

O.Cl.COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC

InChI

1S/C27H38N2O4.ClH.H2O/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H;1H2/t27-;;/m1../s1

InChI key

ICKXRKHJKXMFLR-KFSCGDPASA-N

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301 + H311 + H331

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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