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Q琼脂糖凝胶XL,Q Sepharose XL

Q琼脂糖凝胶XL是一种强阴离子交换剂,设计用于从澄清原料中捕获生物分子的步骤。17507205;17507204;17507260
货号(SKU): 17507201
增值税发票 √ 免费送货 √ 订货电话:010-68689484
₹ 83,653.11

Q Sepharose XL is a strong anion exchanger designed for use in the capture steps of biomolecules from clarified feed-stocks.

高装载能力可以从澄清的原料中获得更高的产量。
专为捕获步骤设计的强阴离子交换剂
用于有效 CIP/消毒的高化学稳定性
基础基质的亲水性确保非特异性结合水平较低,从而导致洗脱池中宿主细胞来源的杂质水平较低。
Q Sepharose XL 基于高度交联的、由珠子形成的 6% 琼脂糖基质,类似于成熟的 Q Sepharose Fast Flow 树脂。葡聚糖链与琼脂糖基质共价偶联,并通过化学稳定的醚键用季铵 (Q) 强阴离子交换基团进行修饰。稳定的琼脂糖基质和带有结合带电基团的葡聚糖的长而灵活的链共同作用以增加负载能力,同时允许高流速。

Q Sepharose XL 具有高负载能力和优异的物理和化学稳定性,适用于下游过程的捕获阶段,其特点是大量的粗样品负载。

作为 BioProcess 树脂系列的一员,Q Sepharose XL 凭借供应安全性以及全面的技术和法规支持满足工业需求。

 

  • High loading capacities give more productive capture from clarified feedstocks.
  • Strong anion exchanger designed for capture steps
  • High chemical stability for effective CIP/sanitization
  • The hydrophilic nature of the base matrix ensures low levels of non-specific binding leading to low levels of host cell-derived impurities in the elution pool.

Q Sepharose XL is based on a highly cross-linked, bead formed 6% agarose matrix similar to the well established Q Sepharose Fast Flow resin. Dextran chains are covalently coupled to the agarose matrix and modified with quaternary ammonium (Q) strong anion exchange groups through chemically stable ether bonds. The stable agarose matrix and long, flexible chains of dextran with bound charged groups work together to increase loading capacity whilst allowing high flow rates.

With its high loading capacities and excellent physical and chemical stability, Q Sepharose XL is suitable for the capture stage of a downstream process, which is characterised by large loads of crude samples.

As member of the BioProcess resins range, Q Sepharose XL meets industrial demands with security of supply and comprehensive technical and regulatory support.

 

ParameterQ Sepharose XL, 300 mL
BioProcess resinYes 
LigandQuaternary amine 
Particle size, d50V1~90 μm 
Ion Exchanger TypeStrong anion exchanger 
Matrix6% cross-linked agarose with dextran surface extenders 
Particle Size45 μm-165 μm 
Ligand Coupling MethodDextran extenders through ether bonds 
Ionic Capacity0.18-0.26 mmol Cl-/ml medium 
pH stability, operational22–12 
pH stability, CIP32–14 
Pressure/Flow Specification300-500 cm/h 
Storage4 to 30°C, 20% Ethanol 
Chemical stabilityCommonly used buffers, nonionic detergents, 1 M NaOH, 6 M guanidine hydrochloride 
Certificate of AnalysisYes 
LicensingFor licensing information, see the Licensing Statements page in the About Us section. 
Pack size300 mL 
  • 1Median particle size of the cumulative volume distribution.
  • 2pH range where resin can be operated without significant change in function.
  • 3pH range where resin can be subjected to cleaning- or sanitization-in-place without significant change in function.
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16