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PNU-120596,≥98% (HPLC)

别名:PNU120596;N-(5-Chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea, NSC 216666

Empirical Formula (Hill Notation): C13H14ClN3O4 CAS号: 501925-31-1 分子量: 311.72 MDL编号: MFCD00095313 PubChem化学物质编号: 329819995 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): P0043
CAS号: 501925-31-1
MDL号: MFCD00095313
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$252.17

说明

包装

5, 25 mg in glass bottle
 

生化/生理作用

An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
α7 烟碱受体的变构调节剂 N-(5-chloro-2,4-dimethoxyphenyl)-N'-(5-methyl-3-isoxazolyl)-urea (PNU-120596),导致细胞外配体结合的构象变化 与乙酰胆碱引起的结构域相似的结构域 PNU-120596 是一种对 α7 烟碱乙酰胆碱受体具有选择性的正变构调节剂。 PNU-120596 对由 α4β2、α3β4、α9α10 nAChRs 介导的电流没有产生可检测的变化。 它增加了通道平均开放时间,但不影响离子选择性。 它不会在激动剂结合位点结合,但会诱导类似于天然效应物的构象变化。
 

特点和优势

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

属性

质量水平

100

测定

≥98% (HPLC)

颜色

white to off-white

溶解性

DMSO: >10 mg/mL

创始人

Pfizer

储存温度

room temp

SMILES string

COc1cc(OC)c(NC(=O)Nc2cc(C)on2)cc1Cl

InChI

1S/C13H14ClN3O4/c1-7-4-12(17-21-7)16-13(18)15-9-5-8(14)10(19-2)6-11(9)20-3/h4-6H,1-3H3,(H2,15,16,17,18)

InChI key

CEIIEALEIHQDBX-UHFFFAOYSA-N

 

安全信息

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16