PHA 767491 hydrochloride，≥98% (HPLC)

图片 PHA 767491 hydrochloride，≥98% (HPLC)
别名：PHA767491盐酸盐；PHA-00767491 hydrochloride, 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo3,2-cpyridin-4-one hydrochloride, 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo3,2-cpyridin-4-one hydrochloride

Empirical Formula (Hill Notation): C12H11N3O · xHCl CAS号: 845538-12-7 分子量: 213.24 (free base basis) MDL编号: MFCD11519962 PubChem化学物质编号: 329823752 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0178
CAS号: 845538-12-7
MDL号: MFCD11519962
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

应用

PHA 767491 hydrochloride has been used to study its effect on estrogen-induced DNA damage.[1] It has also been used in western blot analysis and to study the S9.6 nuclear signal in HeLa cells.[2]
 

生化/生理作用

PHA 767491 serves as a potential anticancer drug.[3] It shows an ameliorating effect against acute myeloid leukemia, colon and breast cancer models. PHA 767491 possesses anti proliferating and apoptotic effect.[4]
PHA-767491 is a potent and selective ATP-competitive dual inhibitor cdc7/cdk9. PHA-767491 blocks DNA synthesis and affects the phosphorylation of the replicative DNA helicase at Cdc7-dependent phosphorylation sites.
 

其他说明

This compound was developed by Pfizer for Kinase Phosphatase Biology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

manufacturer/tradename

Pfizer®

颜色

off-white to yellow

溶解性

H2O: >25 mg/mL

创始人

Pfizer

SMILES string

Cl.O=C1NCCc2[nH]c(cc12)-c3ccncc3

InChI

1S/C12H11N3O.ClH/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12;/h1-2,4-5,7,15H,3,6H2,(H,14,16);1H

InChI key

IMVNFURYBZMFDZ-UHFFFAOYSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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